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Many people, including those over 50, on PPIs or metformin, or with GI conditions, produce insufficient intrinsic factor
Appl Environ Microbiol 68:51555159
But research shows that obesity can increase the risk of heavy, painful periods
The acute anorectic effect of GLP-1 is mediated by GLP-1R located on vagal afferents (88), which relays the signal to appetite control centers, namely the NTS in the brainstem, to reduce food intake (89) (Figure 1)
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