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Whether pharmacological TREK-1 blockade (which is partial and reversible, unlike genetic knockout) carries seizure risk at therapeutic doses is unknown
Taken together, these findings suggest that the antifungal activity of sertraline involves its interaction with the fungal plasma membrane lipid bilayer, leading to structural alterations that ultimately contribute to its fungicidal effects
As with any wellness intervention, it works best as part of a comprehensive program that includes healthy nutrition and regular physical activity
