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Three of the five structures (CBSAOAA, CSECPC and CSEoxamic hydrazide) are oxime-, imine- or oxamic hydrazone-type complexes with PLP in the active site of CBS or CSE (Petrosino et al., 2022
ChemBioChem 2:703705 Townsend SD, Tan Z, Dong S et al (2012) Advances in proline ligation
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Since 90% of the bodys serotonin originates in the gut, modulating enteric serotonin production could influence central serotonergic tone through vagal afferents that relay gut signals to brain serotonin-producing raphe nuclei
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