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When GLP-1 receptors (GLP-1Rs) on intraepithelial lymphocytes (IELs) are activated, there is a decrease in pro-inflammatory cytokine levels, a reduction in the expression of interferon-stimulated genes (ISGs), and a lower rate of apoptosis in epithelial cells [94,95]
The number of patients stopping the medication due to side effects in TRIUMPH-4 were 18.2% on 12 mg, 12.2% on 9 mg, and 4% on placebo
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