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GLP-1 Receptor Agonists In patients with HFpEF and comorbid obesity or type 2 diabetes mellitus, semaglutide has been incorporated into the 2025 JCS/JHFS heart failure guidelines with a Class IIa recommendation (Level of Evidence B), reflecting moderate-quality evidence supporting improvement in symptoms and functional status
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Mood changes such as irritability or feeling low are also common, as well as tingling sensations in the hands and feet that signal nerve involvement
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