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They stimulate insulin secretion in pancreatic -cells, but their effects on glucagon production in pancreatic -cells differ: GIP has a glucagonotropic effect during hypoglycemia, and GLP-1 exhibits a glucagonostatic effect during hyperglycemia
While this has not been observed in humans, it remains a theoretical risk, and patients with a history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) are typically advised against using Semaglutide
Treatment starts at a low dose and is gradually increased to improve tolerability
He points out that most cases resolve with lifestyle changes, medications, and/or in-office procedures
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