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An AI-powered approach could elevate this strategy by designing a hydrogel matrix capable of achieving a zero-order, non-fluctuating release of dopamine, better mimicking natural physiological levels and potentially reducing the side effects associated with pulsed L-DOPA administration
Similarly, trauma induced increased Flavonifractor may potentially compromise GABA availability, since these bacteria primarily utilize GABA for metabolism (Tanelian et al., 2023) potentially affecting this key inhibitory neurotransmitter and contributing to anxiety symptoms observed in PTSD (Strandwitz et al., 2018)
The revealed capacity of DSIP to increase the efficiency of oxidative phosphorylation found in vitro experiments could contribute to understanding pronounced stress protective and antioxidant action of this peptide in vivo
