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FDA banned it in late 2023 "Category 2: Substance with Safety Concerns" Why the FDA banned it: Potential immune reactions (immunogenicity) Manufacturing impurities in compounded versions Complete lack of human safety data Risk of contamination Legal status: NOT FDA-approved Illegal to compound in pharmacies Banned by WADA for athletes Possession not illegal (it's not a DEA scheduled substance) Sold online as "research chemical" 2
The manufacturer sets wholesale pricing uniformly, and while individual pharmacies might add different markups, these variations are modest
That matters if you have trouble absorbing B12 from food or pills, which is more common than most people realize
Interestingly, sigma-1 (Sig1R) agonists, such as BD1047, were shown to downregulate CatB, ameliorating HAND, especially in cocaine users (Lpez et al., 2019)
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