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However, the up to 60% increase in total glutathione in infested resistant plants could not be simply explained by increased stability of glutathione, since Hessian fly did not downregulate genes encoding the putative glutathione degradation enzymes (Figure 5)

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To test the involvement of NRF2, we bred the Gclc f/f mouse strain with the Nrf2 f/f mouse strain 57,58 and induced a liver-specific double deletion with the AAV-TBG-Cre virus (hereafter referred to as L-DKO) (Fig