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A 2010 meta-analysis 24 found that saffron improved symptoms of generalized anxiety and depression compared to placebo, whether used on its own or alongside antidepressants
PRISMA, Preferred Reporting Items for Systematic Reviews and Meta-Analyses
One notable example is this meta-analysis of MTHFR case-control studies, which raises a serious concern: What if only Mendelian randomization studies that found an association have been published
A number of clinical trials have demonstrated that myo-inositol can improve insulin sensitivity and metabolic markers, also influencing ovarian function in women with PCOS
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