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However, the multiplicity of pharmacological treatments managed in these patients can modify gut microbiota composition [56]

This makes combination therapy particularly attractive in resistant cases or where long-term results are needed

127 Another clinical trial in 50 patients with tinnitus, half of whom also had hearing loss, found treatment with intramuscular injections providing 100 mg vitamin B1, 100 mg vitamin B6, and 1,000 mcg vitamin B12 twice weekly led to tinnitus improvement mainly in those without hearing loss