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Two recent meta-analyses of eight cardiovascular outcome trials (CVOTs) and several other meta-analyses that included non-CVOT studies estimated the reduction in cardiovascular mortality varied between 12 and 15% (Zheng et al., 2018
Yes, GLP-1 receptor agonists have demonstrated cardiovascular benefits, such as reducing the risk of heart attack and stroke in individuals with type 2 diabetes and established cardiovascular disease
The ability to cross the rat placenta has been described as low and very limited for sotagliflozin and empagliflozin respectively
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