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Upon ligand binding, the receptor undergoes a conformational change that activates intracellular signalling pathways, primarily through the cyclic adenosine monophosphate (cAMP) second messenger system
Di Monaco, M
An LDLR / mouse-based atherosclerotic model was established to investigate the roles of ALC on atherosclerotic progression
These effects appear to be mediated through improvements in insulin sensitivity, modulation of lipid metabolism, and activation of gene programs involved in enteroendocrine function and thermogenesis (115117)
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