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B12s role in maintaining healthy circadian rhythms may help prevent the sleep disturbances and daytime fatigue commonly experienced with SAD

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UK guidance (MHRA and NICE) advises checking B12 levels in patients on metformin who develop symptoms of deficiency (anaemia, neuropathy) and considering periodic monitoring in those on long-term therapy

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Cell Biology Reports, 34(2), 111127

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May repeat q3-5 minutes if hemodynamically tolerated, to a total dose of 10 mg/kg

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