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The Wnt antagonist DICKKOPF-1 gene is induced by 1, 25-dihydroxyvitamin D 3 associated to the differentiation of human colon cancer cells
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Based on preclinical studies, a systematic review of the neuroprotective mechanisms of GLP-1RA-based therapy in ischemic stroke [67] has shown that administration of drugs of this family before, during, or after an experimental stroke in animals with and without diabetes modulates an acute inflammatory response secondary to brain ischemia, reducing inflammation, endothelial dysfunction and excitotoxicity, as well as decreasing oxidative stress and apoptosis
The gradual titration approach remains essential regardless of target dose to minimize gastrointestinal side effects
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