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PubMed Kleinert, M., Sachs, S., Habegger, K.M., Hofmann, S.M., & Mller, T.D
doi: 10.1371/journal.pone.0127244 125 SimpsonD
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The observation that patients with AD carrying two alleles of the APOE4 risk variant have approximately half the cerebrospinal fluid (CSF) melatonin levels compared to those with only one allele of this variant [75] could suggests that APOE4/4 carriers might particularly benefit from supplementing with exogenous melatonin
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