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Although the etiology of depression has not been fully elucidated, current scientific data emphasize the role of neurotrophic factors deficiencies, disturbed homeostasis between the nervous system and the immune and endocrine systems, as well as disturbances in brain energy metabolism and dysfunctions in the gut-brain axis as important factors in the pathogenesis of this neuropsychiatric disorder
Weight loss typically involves losing both fat and muscle, but lean muscle mass requires significant energy to maintain, playing a crucial role in your basal metabolic rate
Diabetologia 41 , 271278 (1998)
Wang K, Dai XZ, He JH, Yan XQ, Yang CK, Fan X, et al
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