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The FDA has approved the use of L-carnitine (by mouth or intravenously) treating L-carnitine deficiency caused by certain genetic diseases, end-stage kidney disease, and other disorders
Weight-loss drugs like semaglutide may melt fat, but at the cost of muscle mass
Although all identified CerS enzymes exhibit similar Km values (affinity for substrates), they vary in their selectivity for acyl-CoAs depending on the length of the acyl chain ( The role of ceramides in the brain is essential for maintaining the structure and function of cell membranes, contributing to their integrity, fluidity and stability (Mencarelli and Martinez-Martinez, 2013)
The cardiometabolic upside is smaller because the baseline risk is smaller
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