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Concurrently, GLP-1 also reduces fat build-up in the liver by activating AMPK, which then inhibits fatty acid synthesis while promoting the breakdown of fatty acids (beta-oxidation), leading to less lipid droplet accumulation in hepatocytes

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Some pharmacies assign a 28-day BUD as a conservative baseline

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By activating both receptor systems, tirzepatide appears to produce greater weight loss than GLP1 agonists alone

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