By the time three months have passed, your slimmer shape is readily noticeable
Early studies showed a small, statistically detectable weight-loss signal at some doses, but larger and longer trials did not separate clearly from placebo on their primary endpoints, and the drug was not pursued to approval for obesity
group, the Sarcopenia Definition and Outcomes Consortium (SDOC), went further: pooling data from more than 18,000 participants across eight epidemiologic studies and six randomized trials, SDOC found that DXA-measured lean mass did not predict falls, fractures, mobility limitation, or mortality once other factors were accounted for
Last updated: January 28, 2026 As GLP-1 medications like Ozempic, Wegovy, and Mounjaro help more patients achieve significant weight loss, many are discovering that reaching their goal weight reveals new concerns: stubborn fat pockets and loose abdominal skin that diet and exercise cannot address