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Weeks 9 through 12 at 8mg typically produces the most dramatic changes

These oxidative modifications can result in misfolded protein conformations and the exposure of hydrophobic patches, which are prone to aggregation [184]

19,20 Salvage pathway Rather than generated de novo, most NAD + is recycled from NAM, NA, NR and NMN in the salvage pathway to maintain the cellular NAD + levels