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Tirzepatide, due to its dual mechanism of action, may lead to enhanced weight loss
corroborated by Oostdyk 2024) and downregulates surface GLP-1R within 12 hours at physiological albumin (Hinds 2024), so the sustained signal held against that fade, set by dose, is what carries the effect
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This could be due to ALCs quick absorption and capacity to cross the blood-brain barrier, potentially altering the gut microbiota composition and limiting the abundance of TMA-producing bacteria
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