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Gianello (PubMed) Research Focus : Mechanistic Preclinical Research Title : Development of a Human Growth Hormone Peptide Analogue AOD9604 into an Anti-Obesity Drug (Book chapter, Peptides: The Wave of the Future, APSY vol 7, 2001) Authors : Woei-Jia Jiang, Robert Gianello, Mark Heffernan, Esra Ogru, Roksan Libinaki, Frank Ng (SpringerLink) Research Focus : Preclinical Lipid Metabolism Studies (Mice) Title : The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and -AR knockout mice (Endocrinology, Dec 2001) Authors : M
This multi-route evaluation demonstrated that AOD-9604s favorable safety profile was not dependent on a specific delivery method, though bioavailability differed between routes
While these findings remain encouraging, much of the published evidence has been generated through laboratory and animal models, and additional research is needed to further define its biological effects
While AOD-9604 mobilizes fat without preserving muscle, ipamorelin's GH elevation provides some muscle-protective effect
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