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Important safety considerations include a boxed warning for thyroid C-cell tumors (contraindicated in patients with Multiple Endocrine Neoplasia syndrome type 2), and risks of pancreatitis, gallbladder disease, acute kidney injury from dehydration, and hypoglycemia when used with insulin or sulfonylureas

Interestingly, research on the Na + -dependent glutathione transporter for brain targeting has been limited despite the fact that the glutathione transporter is selectively distributed in the brain, kidneys, and small intestine

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Reduced risk of cirrhosis