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Horsham and Marren, semaglutide should be avoided for the following medical conditions or situations: Type 1 diabetes mellitus A history of medullary thyroid cancer (MTC) Chronic abdominal pain Chronic vomiting A medical history of pancreatitis A family history of multiple endocrine neoplasia type 2 (MEN 2) Hypersensitivity to the drug or its components Severe gastrointestinal diseases, such as gastroparesis Are pregnant or breastfeeding I also warn patients with a history of gallstones or gallbladder disease that still have a gallbladder that losing weight (and not necessarily the medication itself) can worsen these conditions, Dr