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2 Neuroinflammation in depressive disorder: multidimensional pathogenic mechanisms Neuroinflammation is an evolutionarily conserved defense mechanism in the CNS, triggered by insults such as infection or injury and mediated through the coordinated activation of resident glial cells and recruited immune cells (Kopp et al., 2022)

68 In contrast, subclonal neoantigens are confined to specific tumor subpopulations and are more likely to be retained under immune selection pressure, thereby serving as a major source of immune escape and relapse

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Neurological Disorders Related to B12 Deficiency Vitamin B12 deficiency can cause problems like nerve damage, memory loss, and dementia