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Trial investigators were explicitly allowed to hold a step for an extra 4 weeks or drop back a level, and did so often
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Mistake 2: Shaking the vial to dissolve Vigorous shaking creates shearing forces between liquid layers that can damage peptide bonds
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Cerebellum 10:4348
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However, if the goal is specifically treating post-acne marks, sun spots, or melasma patches defined areas of hyperpigmentation topical kojic acid is the more targeted, better-evidenced, and significantly lower-risk approach
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