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The authors systematically searched PubMed and Embase from inception to 1 May 2025 for cohort studies comparing the effect of combination therapy with SGLT2 inhibitor or GLP-1 RA monotherapy on (cardiovascular) mortality and cardiovascular or kidney endpoints in individuals with type 2 diabetes

Five metabolites (L-acetylcarnitine, L-carnitine, ribonic acid, glucaric acid, and taurine) were significantly increased in a group of patients that received acetazolamide oral administration (Supplementary Fig

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