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In experimental models, OLETF rats have shown local RAS activation, which resulted in oxidative stress and kidney progressive damage, whereas treatment with dapagliflozin remarkably lowered the urinary ANG II and AGT levels (36)

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The second antibody was a biotinylated goat anti-rabbit immunoglobulin, and the signal was detected using the Vectastain ABC kit (Vector Laboratories, Burlingame, California, USA) with DAB as a substrate

Your weight fluctuates daily by 2-4 pounds based on hydration, food intake, and bowel content