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SOUL Published in the New England Journal of Medicine , SOUL was a double-blind, placebo-controlled, event-driven superiority trial, enrolling 9650 participants who were randomised to receive oral semaglutide (up to 14 mg once daily) or placebo, alongside standard care for diabetes and CVD (McGuire et al, 2025)

1,25-Dihydroxyvitamin D3 activates MMP13 gene expression in chondrocytes through p38 MARK pathway

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