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In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]

It remains one of the most studied compounds in the field of peptide bioregulation theory, a framework developed to explain how short peptide chains may influence tissue-specific gene expression

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