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In one study, mass spectrometry was used to analyze body fluid samples from patients with depression, revealing significant changes in various metabolites, including long-chain fatty acids and amino acids

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Researchers found that, compared with healthy controls, the levels of trimethylamine oxide, glutamine, and lactic acid in the plasma of patients with depression were significantly increased, while the levels of phenylalanine, valine, alanine, glycine, leucine, citrate, choline, lipids, and glucose were significantly decreased