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Alternative GLP-1 receptor agonists may be considered, as different formulations can have varying effects on gastric emptying and individual tolerance: Dulaglutide (Trulicity) another once-weekly injection with a potentially different side-effect profile Liraglutide (Victoza) a daily injection that some patients tolerate differently Exenatide available in both twice-daily and once-weekly formulations Whilst all GLP-1 receptor agonists share similar mechanisms of action and potential for gastrointestinal effects, individual patient responses can differ, and a trial of an alternative agent may prove beneficial
Dose reduction can also reduce side effects and cost
To view a copy of this licence, visit About this article Cite this article Solini, A., Tric, D
However, some mild side effects may occur, especially during the adjustment period or at higher doses: Headaches Temporary injection site irritation Lightheadedness Water retention (in rare cases) Mild tingling or numbness (from elevated IGF-1) Ipamorelin induced growth hormone release without elevating cortisol or ACTH levels, suggesting minimal off-target effects. Raun et al., European Journal of Endocrinology Compared to Other Peptides Unlike GHRP6 , which often causes intense hunger and spikes in prolactin , or GHRP2 , which can increase cortisol , Ipamorelin is more targeted and stable
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