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This AMPK-Nrf2 axis is critical for maintaining redox balance and mitochondrial integrity in skeletal muscle (Wang et al., 2022)
M1 macrophages arrive first to eat dead cells and fight infection
This may include: Neurological exam to rule out focal deficits Fundoscopic exam to check for papilledema MRI brain with and without contrast if red-flag features present Lumbar puncture with opening pressure measurement if idiopathic intracranial hypertension suspected Discussion of temporary dose reduction or treatment pause Why the headache gets worse during dose escalations The dose-response relationship for GLP-1 headaches is real but modest
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