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It is metabolized into several peptide fragments, primarily involving proline-rich sequences, and eliminated with a half-life under 30 minutes
TABLE 9 Relative bioavailabilities of diosgenin, charantin, and hydroxychalcone in the formulation without piperine (F1), formulation with piperine (F2), and oral pure drug administration
May cause headache, nausea, abdominal discomfort, constipation, flatulence, or dizziness
Limitations: Lower Bioavailability: Even with liposomal forms, absorption may not match IV levels
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