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The goal is to make the scar and surrounding tissues more pliable

CRLX101 illustrates this vascular-oriented logic as a cyclodextrin-based camptothecin nanoparticle associated with high intratumoral accumulation, HIF-1 pathway modulation, reduced hypoxic regions and improved drug distribution in selected preclinical or early clinical settings [90,91,92,93,94,95]

J Cell Biol 2 July 2018

2 Establishing the correct diagnosis of malignant peripheral nerve sheath tumor remains a challenge not only due to morphological and immunohistochemical complexity (particularly outside the NF1 context) but also because a number of other sarcomas, benign soft tissue tumors, and non-epithelial tumors (especially melanoma) can appear similar to malignant peripheral nerve sheath tumors