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Safety Concerns When Combining These Two Medications The primary safety issue with simultaneous semaglutide and phentermine use involves cardiovascular strain, as both medications can elevate heart rate and blood pressure through different mechanisms
On the other hand, limitations in available GLP-1RA choices have led to selection biases, particularly in the early 2010s and in regions where access to other GLP-1RAs was relatively delayed
doi:10.1101/gr.9.12.1175
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