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Source: University of Georgia

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Acetyl coenzyme A (Acetyl-CoA), produced through the metabolism of glucose, fatty acids, and amino acids [7], is utilized in cholesterol synthesis, a process regulated by SREBP-2 through the enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol biosynthesis

However, gut repair processes accelerate during sleep when digestive activity decreases and cellular regeneration predominates, potentially favoring evening administration for conditions like inflammatory bowel disease or leaky gut