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Three to four resistance training sessions per week, focusing on compound movements like squats, deadlifts, presses, and rows, provides sufficient stimulus to preserve and even build muscle during calorie restriction
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Why dual agonism matters: GIP receptors in fat tissue may improve fat metabolism Combined signaling creates stronger insulin response SURMOUNT trials showed up to 22.5% weight loss (vs 15% for semaglutide) Sources: Tirzepatide once weekly for treatment of obesity (SURMOUNT-1) Dual GIP/GLP-1 receptor agonism mechanisms B
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