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Ortiz et al., 2025)
NNT knockdown shows limited ability to maintain NADPH levels and reduces tumorigenicity under oxidative stress conditions, such as that induced by anoikis, glucose deprivation in vitro, or impairs peritoneal dissemination and lung metastasis in vivo
Glutathione (GSH) is synthesized in the cytoplasm in virtually all cells from its constituent amino acids by two sequential ATP-requiring enzyme-catalyzed reactions (see figure below) [1]
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