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When someone carries excess weight AND has an autoimmune condition, they face a compounding problem: obesity-driven inflammation amplifies autoimmune-driven inflammation, creating a feedback loop that standard immunosuppressive therapies struggle to fully address

That range describes where results typically land

Construction and validation of a novel ferroptosis-related prognostic model for acute myeloid leukemia

Mechanistically, ACSL4 upregulation enhances c-Myc activity, which in turn promotes the transcriptional activation of sterol regulatory element-binding protein 1 (SREBP1), a master regulator of fatty acid and cholesterol biosynthesis