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ADA Standards of Care 2025) recommend that patients with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD) (or high risk) should be on a GLP-1 RA with proven CV benefit (or an SGLT2 inhibitor) as part of their regimen, independent of A1c, because of the outcome benefits ( [9] ) ( [144] )
35 An example of this prophylactic treatment of near-threshold retinopathy would be to initiate intravitreal anti-vascular endothelial growth factor therapy for central macular edema that does not meet criteria for CI-DME rather than observing
Pediatr.Nephrol
That said, phentermine still has a role for certain patients, particularly when short-term, oral therapy is preferred or when cost and accessibility are primary concerns
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