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360 Additionally, studies have shown that the expression of PGC-1-responsive genes is downregulated in the brains of PD patients, possibly due to hypermethylation of PGC-1 transcriptional elements, leading to bioenergetic dysregulation
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Unlike conventional DAT blockers such as methylphenidate, the disruption of D2R-DAT leads to decreased membrane expression of DAT, while leaves the remaining DAT functional to facilitate the reuptake of dopamine [23]
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