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Weight regain after discontinuation of GLP-1 class medications is well-documented the STEP 1 extension trial showed that most weight lost on semaglutide was regained within a year of stopping treatment
The practical differences in early experience look like this: Semaglutide onset: Most users notice initial appetite changes within 1 to 3 weeks
Moreover, they have no minimum commitment, which most weight loss programs have nowadays
Your provider will help you determine the right timeline and approach to transitioning off medication safely
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