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In some approved medicines, PEGylation has been used successfully to extend dosing intervals or improve exposure, but each PEGylated product must be evaluated on its own chemistry, target, and safety profile [13] [14]
In a split-face randomized study (N=67) evaluating a 1% GHK-Cu serum over 12 weeks, 12% of participants reported transient erythema in the first two weeks, resolving spontaneously without discontinuation (Leyden et al., 2018, see related wound-healing data at NCBI)
