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The gonadal hormone 17-estradiol (E2) favours reproductive, bone, cardiovascular and neuronal physiology via activation of estrogen receptors (ERs) 1
Am J Clin Nutr (2006) 84:5515
Weeks 5 to 8 (0.5 mg, 10 units at 5 mg/mL): Appetite suppression becomes more noticeable
However, Valente noted that they are "likely not going to be a full meal replacement at only about 200 calories for most, but maybe pairing them with something small or sipping them throughout the day when you don't have an appetite would be smart." Of course, as Valente noted, you can also replicate "a healthy, balanced smoothie at home using fruit, some greens, and protein powder with milk or non-dairy milk."
