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Using the International Diabetes Federation definition of metabolic syndrome (central obesity plus any two of the following: raised triglycerides, reduced high-density lipoprotein cholesterol, raised blood pressure, and raised fasting glucose), the researchers found that 9% randomized to TAF/FTC+DTG, 5% randomized to TDF/FTC+DTG, and 3% randomized to TDF/FTC+EFV had metabolic syndrome at week 96

10.1146/ANNUREV.GE.22.120188.003215 105 LiuS.LiJ.TaoY.XiaoX

The cell cycle proteins S-phase kinase-associated protein-2 (Skp2) and Cyclin B1 are ubiquitinated and degraded by the E3 ligase APC/C

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