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In fact, animal metabolism does not distinguish between methionine and cysteine (sulfur forms) and their selenium analogs (cited by Daniels, 1996)

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The guidance recommends testing for people with at least one sign or symptom and one or more risk factors for the condition

Baertling, F, Rodenburg, RJ, Schaper, J, Smeitink, JA, Koopman, WJH, Mayatepek, E, Morava, E, Distelmaier, F 2014, A guide to diagnosis and treatment of Leigh syndrome, Journal of Neurology, Neurosurgery & Psychiatry , vol