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[11] These agents bind to GLP-1 receptors expressed throughout the body, including pancreatic beta cells, the gastrointestinal tract, and central nervous system regions involved in appetite regulation
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While not shown, this is most likely mediated by activation of GLP-1Rs in upstream CCK-expressing NTS neurons by exendin-4 since NE-expressing NTS neurons do not appreciably express GLP-1Rs [66]
(It is difficult to get insurance to cover the cost of this medication for weight loss.) The average monthly cost of Mounjaro at a commercial pharmacy is around $1,000 to $1,300 per month
