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This is the window that the Finkley 2005 trial captured, and the Carey/Pickart ultrasound work confirmed at the structural level: an average 28% increase in collagen density, with top responders at 51%
However, by supporting weight loss and better blood sugar control, many people report feeling more energetic and motivated as their overall health improves during treatment.
Similarly, a 2022 meta-analysis 12 on 34 randomized controlled trials found positive effects of melatonin versus placebo in both adult populations and child/adolescent populations
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